| Year | Award | Category | Film | Result |
| 1998 | Emmy Award | Outstanding Supporting Actress in a Miniseries or a Movie | George Wallace | Nominated |
| Golden Globe Award | Best Supporting Actress – Series/Miniseries/TV Movie | Won |
| National Board of Review Award | Breakthrough Performance – Female | Playing by Heart | Won |
| Emmy Award | Outstanding Lead Actress in a Miniseries or a Movie | Gia | Nominated |
| 1999 | Golden Globe Award | Best Performance by an Actress in a Mini-Series or Motion Picture Made for TV | Won |
| Screen Actors Guild Award | Outstanding Performance by a Female Actor in a TV Movie or Miniseries | Won |
| 2000 | Golden Globe Award | Best Supporting Actress – Motion Picture | Girl, Interrupted | Won |
| Screen Actors Guild Award | Outstanding Performance by a Female Actor in a Supporting Role | Won |
| Academy Award | Performance by an Actress in a Supporting Role | Won |
| 2004 | People's Choice Award | Favourite Female Action Star | Sky Captain And The World Of Tomorrow | Won |
| 2008 | Golden Globe Award | Best Performance by an Actress in a Motion Picture – Drama | A Mighty Heart | Nominated |
| Screen Actors Guild Award | Outstanding Performance by a Female Actor in a Leading Role | Nominated |
| 2009 | Golden Globe Award | Best Performance by an Actress in a Motion Picture – Drama | Changeling | Nominated |
| Screen Actors Guild Award | Outstanding Performance by a Female Actor in a Leading Role | Nominated |
| BAFTA Award | Best Actress in a Leading Role | Nominated |
| Academy Award | Performance by an Actress in a Leading Role | Nominated |
| (Source: IMDb.com) |
